A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer. (21st January 2015)

• Record Type: Journal Article
• Authors: Zhao, Nan; Yang, Ruijie; Jiang, Yuliang; Tian, Suqing; Guo, Fuxin; Wang, Junjie
• Other Names: Hande Manoor Prakash Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-01-21
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/940102
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P = 0.00 ) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P = 0.00 ). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.