Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas. (3rd August 2015)

• Record Type: Journal Article
• Authors: Tolia, Maria; Verganelakis, Dimitrios; Tsoukalas, Nikolaos; Kyrgias, George; Papathanasiou, Matilda; Mosa, Eftichia; Kokakis, Ioannis; Kouvaris, John R.; Pissakas, George; Pistevou-Gombaki, Kyriaki; Kelekis, Nikolaos; Kouloulias, Vasileios
• Other Names: Topolcan Ondrej Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-08-03
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/341042
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Purpose . We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas. Materials and Methods . Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS). Results . The median RFS was 26.06 months. RFS was significantly worse in elderly patients ( P = 0.001 ) along with the higher choline/creatine ratios at either baseline ( P = 0.003 ) or six months post Radiotherapy ( P = 0.042 ) . Median RFS was 23 months in high choline/creatine levels ≥2 at 6 months after radiotherapy and 11 months for those with <2 choline/creatine levels. There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P = 0.045 ). Conclusion . Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas.