Successful pregnancy via in vitro fertilization in a primary infertile woman with primary lymphoma of the fallopian tube after surgery: A case report and literature review. Issue 30 (29th July 2022)

• Record Type: Journal Article
• Authors: Zhang, Jie; Hou, Zhen; Huang, Jie; Xu, Wei; Wang, Cong; Ma, Xiang; Lu, Nan; Liu, Jiayin; Mao, Yundong; Qian, Yi
• Is Part Of: Medicine. Volume 101:Issue 30(2022)
• Page Start: e29353
• Publication Date: 2022-07-29
• Subjects: B-Cell -- fallopian tube -- infertility -- lymphoma -- marginal zone; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000029353
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Rationale: Primary extranodal marginal zone B-cell lymphomas of the fallopian tube is extremely rare. It is a great challenge for fertility and gynecology doctors to manage such cases and also fulfil the reproductive demands of these young women. Patient concerns: A 30-year-old woman consulted for a 5-year primary infertility. Diagnosis: According to the Ann Arbor staging system, a stage IE extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma was diagnosed for this patient based on tumor pathology, bone marrow biopsy, hysteroscopy and whole-body positron emission tomography imaging. She also had endometriosis based on laparoscopy. Interventions: The patient underwent a laparoscopic bilateral salpingostomy without additional surgery or radiotherapy and chemotherapy for fertility preservation, and received 5 months of long-acting gonadotropin releasing hormone agonist treatment for endometriosis. Outcomes: Two years after the surgery, the patient delivered a healthy neonate through in vitro fertilization-embryo transfer procedures. The patient is now 3 years post-op and 1 year post-delivery, long-term follow-up suggested that the patient remained cancer-free up till now. Lessons: More care should be taken when the newly diagnosed mass is combined with a rather high serum CA-125 level. Although endometriosis and ovarian cancer are more common, lymphoma cannot be ruled out.