Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. (13th September 2017)

• Record Type: Journal Article
• Authors: Dattola, Vincenzo; Bonanno, Lilla; Naro, Antonino; Chillura, Antonino; Logiudice, Anna Lisa; Sessa, Edoardo; Famà, Fausto; Quartarone, Angelo; Calabrò, Rocco Salvatore; Marino, Silvia; Russo, Margherita
• Other Names: Prosperini Luca Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-09-13
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/5421416
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Interferon beta (IFN- β ) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN- β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN- β -1A on the function of cerebral vessels in a cohort of RRMS patients. Using transcranial Doppler (TCD) ultrasound, we measured the mean blood flow velocity (MFV) in intracranial vessels 10 h after IFN- β administration. Measurements showed a significant increase in MFV compared to the baseline values in some vessels.