Subacute oral toxicity of ayurvedic anti-diabetic preparation Jambadyarista in Sprague-Dawley rats. (2020)

• Record Type: Journal Article
• Authors: Hasan, Mahedi; Mahmud, Abdullah Al; Alam, Md. Jahir; Siddiqui, Shafayet Ahmed; Arman, Md. Saiful Islam; Mahmud, Muhammed Hasan; Amin, Mohammad Nurul; Imtiaz, Omar; Shahriar, Masum; Jakaria, Md.
• Is Part Of: Toxicology reports. Volume 7(2020)
• Page Start: 1616
• Page End: 1621
• Publication Date: 2020
• Subjects: Jambadyarista -- Sub acute toxicity -- Ayurvedic -- Biochemical parameters -- Hematological parameters; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2020.11.011
• Languages: English
• ISSNs: 2214-7500

Abstract

Graphical abstract: Highlights: Jambadyarista, an Ayurvedic formulation used in the management of diabetes and its related complications. This study investigated the subacute oral toxicity of Jambadyarista in a rat model. Biochemical and hematological parameters were studied after 28-day of treatment. Evidence of mortality and change in observed parameters were not seen that proves the oral safety of Jambadyarista. Abstract: Background: Jambadyarista is an Ayurvedic polyherbal formulation widely prescribed by Ayurvedic practitioners for the management of diabetes and its associated complications. About 39 companies have marketed this formulation in Bangladesh with consent from the Directorate General of Drug Administration (DGDA). Aim: This study investigated the sub-acute oral toxicity of Jambadyarista in the Sprague-Dawley rat model. Methods: The sub-acute toxicity studies were executed in Sprague-Dawley rats. Jambadyarista formulation was given for 28-days through oral gavage at 10 mL/kg and 20 mL/kg dose to two different groups comprising 6 rats of both sex/groups. Across the experimental period mortality, adverse reactions were closely monitored. After 28-day feeding hematological, biochemical, and relative organ weights were quantified. Results: No mortality and/or signs of morbidity were observed for 28-day of repeated-dose sub-acute toxicity. Any pernicious change in body weight, biochemical, and hematological parameters along with relative organ weight were not observed for Jambadyarista. Correlation study among parameters of the renal profile, liver profile, lipid profile also metabolic hormones (T3 and TSH), and enzymes showed the non-toxic rather beneficial role (hypolipidemic) of Jambadyarista in Sprague-Dawley rats. Conclusion: Jambadyarista preparation did not cause any potential toxic effect in repeated dose subacute toxicity study over Sprague-Dawley rats orally. Therefore, low dose administration of Jambadyarista could have a beneficial effect on diabetes and can be considered safe before the chronic study.