Ε‑Polylysine-stabilized agarose/polydopamine hydrogel dressings with robust photothermal property for wound healing. (15th July 2021)

• Record Type: Journal Article
• Authors: Qi, Xiaoliang; Pan, Wenhao; Tong, Xianqin; Gao, Teng; Xiang, Yajing; You, Shengye; Mao, Ruiting; Chi, Jun; Hu, Rongdang; Zhang, Wenzhen; Deng, Hui; Shen, Jianliang
• Is Part Of: Carbohydrate polymers. Volume 264(2021)
• Publication Date: 2021-07-15
• Subjects: ε-Polylysine -- Polydopamine -- Hydrogel dressing -- Photothermal stabilization -- Wound healing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118046
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A hybrid hydrogel (ADPH) composed of ε-Polylysine, polydopamine and agarose was synthesized. ADPH showed stable photothermal functionality and desirable physicochemical properties. ADPH possessed excellent biocompatibility and photothermal sterilization efficiency. ADPH significantly promoted wound healing by regulating bacteria-induced inflammation. Abstract: Polydopamine (PDA) is emerging as an attractive photothermal agent due to its good photothermal performance and excellent biocompatibility. However, without chemical modification, PDA is normally unstable and usually leached out from the constructed biomaterials, realistically limiting its application space. Here, we constructed a new hydrogel dressing with robust and stable photothermal performance by introduction of ε-Polylysine (ε-PL) into agarose/PDA matrix to efficiently lock PDA. By optimizing PDA/ε-PL rational dose in agarose network structure, a hybrid agarose/PDA/ε-PL hydrogel (ADPH) with stable photothermal functionality and desirable physicochemical properties could be achieved. ADPH possessed satisfactory microbicidal efficacy in vivo, which enabled the bacteria-infected skin wound to be cured quickly by successful suppressing inflammation, accelerating collagen deposition and promoting angiogenesis in a bacterial-infected wound model. Collectively, this study illustrates a simple, convenient but powerful strategy to design functionally stable ADPH dressing for treating dermal wounds, which could open vistas in clinical wound management.