Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Omar, Hanita; Fadaeinasab, Mehran; Taha, Hairin; Widyawaruyanti, Aty; Nafiah, Mohd Azlan; Rachmatiah, Tiah
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 1(2020)
• Page Start: 52
• Page End: 60
• Publication Date: 2020-01-02
• Subjects: Phoebe tavoyana -- Lauraceae -- aporphine alkaloid -- morphinandienone -- antiplasmodial -- Plasmodium falciparum; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1553958
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: One new aporphine named tavoyanine A (1 ), along with four known aporphines laetanine (2 ), roemerine (3 ), laurolitsine (4 ), and boldine (5 ), and one morphinandienone type sebiferine (6 ) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3 ), laurolitsine (4 ), boldine (5 ), and sebiferine (6 ). The results showed that 3 –6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. Graphical Abstract: