2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11. Issue 6 (3rd June 2019)

• Record Type: Journal Article
• Authors: Si, Ying-Ying; Tang, Ming-Xu; Lin, Shuang; Chen, Gang; Hua, Hui-Ming; Bai, Jiao; Wang, Yu-Bo; Wang, Hai-Feng; Pei, Yue-Hu
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 6(2019)
• Page Start: 528
• Page End: 534
• Publication Date: 2019-06-03
• Subjects: OSMAC -- fumiquinazoline-type alkaloid -- Aspergillus -- Aspergillus flavipes; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1463999
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1 ), together with six known compounds (2–7 ), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was determined by the experimental and calculated ECD data. In addition, the cytotoxic activities against three human cancer cell lines (HL-60, THP-1, and PC-3) were evaluated. Abstract : UF0001