A new flavanol from the roots of Daphne genkwa. Issue 12 (2nd December 2019)

• Record Type: Journal Article
• Authors: Wang, Rui; Tong, Ling; Liu, Cai-Yun; Guo, Cong
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 12(2019)
• Page Start: 1215
• Page End: 1220
• Publication Date: 2019-12-02
• Subjects: Daphne genkwa -- Thymelaeaceae -- flavanol -- structure -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1530222
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The phytochemical investigation of the roots of Daphne genkwa yielded six secondary metabolites, including a new flavanol derivative, (2R, 3S)-5, 7, 4′-trihydroxy-8-methoxycarbonylflavanol (1 ), and five known compounds (2 –6 ). The molecular structures of the isolated constituents were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, the cytotoxic activity of 1 and 2 against A549, HL-60, SMMC-7721, MCF-7, and SW480 cell lines was also described. Graphical Abstract: uf0001