Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes. (3rd May 2020)

• Record Type: Journal Article
• Authors: Li, Hui; Lu, Aoyun; Zhang, Yanqiu; Peng, Yanqing; Song, Gonghua
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 195:Number 5(2020)
• Page Start: 371
• Page End: 375
• Publication Date: 2020-05-03
• Subjects: Azabicyclo -- PWNs -- nematicidal activity -- novel nematicide; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2019.1700260
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes ( Bursaphelenchus xylophilus ) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e ), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a ) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e ) exhibited more than 90% mortality against Bursaphelenchus xylophilus . Graphical Abstract: uf0001