One-pot synthesis of nucleotides in water medium. (27th May 2019)

• Record Type: Journal Article
• Authors: Depaix, Anaïs; Peyrottes, Suzanne; Roy, Béatrice
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 194:Number 4/6(2019)
• Page Start: 335
• Page End: 336
• Publication Date: 2019-05-27
• Subjects: Nucleosides -- phosphorylation -- synthetic methods -- water chemistry; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2018.1541239
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: We developed a one-pot two-steps approach in an aqueous medium to synthesize nucleoside 5'-di- and 5'-triphosphates, dinucleoside 5', 5'-polyphosphates as well as some nucleotide analogs modified either on the nucleoside or on the phosphate moieties. The attractive features of this strategy include absence of protecting groups on the starting material and convenient set-up (i.e., use of water and reagents commercially available as sodium or potassium salts). Graphical Abstract: uf0001