Cytotoxic lycodine alkaloids from the aerial parts of Lycopodiastrum casuarinoides. Issue 3 (3rd March 2020)

• Record Type: Journal Article
• Authors: Zhang, Hai-Bo; Hu, Jiang; Li, Jia-Xun; Hao, Shan-Hu
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 3(2020)
• Page Start: 217
• Page End: 224
• Publication Date: 2020-03-03
• Subjects: Lycopodiastrum casuarinoides -- Lycopodiaceae -- lycodine alkaloids -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1552681
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A phytochemical investigation on the 75% EtOH extract of the aerial parts of Lycopodiastrum casuarinoides resulted in the isolation of three new lycodine alkaloids, 16-hydroxy-9-oxo-lycocasuarinine D (1 ), 6 α -hydroxy-16-dehydroxy-lycocasuarinine A (2 ), and 6 α, 16-dihydroxy-lycocasuarinine B (3 ). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, infrared, ultraviolet, and HR-ESI-MS. The isolated alkaloids were tested in vitro for cytotoxic potential against six lung cancer cell lines. Consequently, alkaloid 1 exhibited cytotoxicity against all the tested tumor cell lines with IC50 values less than 20 μM.