Management of nitrobenzene poisoning with oral methylene blue and vitamin C in a resource limited setting: A case report. (2020)

• Record Type: Journal Article
• Authors: Shrestha, Ninadini; Karki, Bipin; Shrestha, Pramesh Sunder; Gami, Rupesh; Acharya, Subhash Prasad; Acharya, Santosh
• Is Part Of: Toxicology reports. Volume 7(2020)
• Page Start: 1008
• Page End: 1009
• Publication Date: 2020
• Subjects: Methemoglobinemia -- Methylene blue -- Nitrobenzene -- Vitamin C; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2020.08.012
• Languages: English
• ISSNs: 2214-7500

Abstract

Graphical abstract: Highlights: Though intravenous methylene blue is a well established treatment modality for methhaemoglobinemia, there is limited experience with oral preparation. Oral methylene blue was used successfully in a case of nitrobenzene poisoning since intravenous preparation was not available in our setting. An oral dose of 2 mg/kg has been found to be safe and effective for other disease conditions. We too successfully managed the patient with this oral dose. Abstract: Nitrobenzene can cause life threatening methaemoglobinemia. Its management includes the use of intravenous methylene blue to reduce the iron moiety from its ferric to ferrous state. Due to unavailability of intravenous preparation, enteral methylene blue was used in our case. This case report is to highlight that even oral preparations can be successfully used in a resource limited setting where often intravenous preparations are unavailable.