A new xanthyletin-type coumarin from the roots of Peucedanum praeruptorum. Issue 3 (3rd March 2020)

• Record Type: Journal Article
• Authors: Li, Xin-Yu; Zu, Yuan-Yuan; Ning, Wei; Tang, Ming-Xu; Gong, Chi; Niu, Sheng-Li; Hua, Hui-Ming
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 3(2020)
• Page Start: 287
• Page End: 294
• Publication Date: 2020-03-03
• Subjects: Peucedanum praeruptorum -- xanthyletin-type coumarin -- absolute configurations -- antiproliferation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1551887
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new xanthyletin-type coumarin, neopeucedalactone (1 ), was isolated from the roots of Peucedanum praeruptorum Dunn. Its chemical structure was elucidated based on extensive spectroscopic interpretation. The absolute configurations of xanthyletin-type coumarin were determined by comparing experimental and calculated ECD spectra for the first time. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60, THP-1 cell lines, and human prostate cancer PC-3 cell lines, with IC50 values of 9.97, 27.80, and 48.68 µM, respectively.