Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Yin, Zhao-Kun; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Xu; Zhang, Pei-Cheng; Yang, Ya-Nan
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 1(2020)
• Page Start: 24
• Page End: 29
• Publication Date: 2020-01-02
• Subjects: Labiatae -- Salvia miltiorrhiza -- tanshinone diterpene derivatives -- antiviral activity -- isolation and purification -- structure elucidation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1645132
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza . Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC50 = 0.67 μ M) and oseltamivir (IC50 = 2.01 μ M) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC50 values of 11.11 and 8.62 μ M, respectively. Graphical Abstract: