Measurement of Liver Iron Concentration by MRI Is Reproducible. (22nd March 2015)

• Record Type: Journal Article
• Authors: Alústiza, José María; Emparanza, José I.; Castiella, Agustín; Casado, Alfonso; Garrido, Adolfo; Aldazábal, Pablo; San Vicente, Manuel; Garcia, Nerea; Asensio, Ana Belén; Banales, Jesús; Salvador, Emma; Moyua, Aranzazu; Arozena, Xabier; Zarco, Miguel; Jauregui, Lourdes; Vicente, Ohiana
• Other Names: Niggemann Pascal Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-03-22
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/294024
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Purpose . The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. Materials and Methods . A phantom reproducing the liver/muscle ratios of two patients with intermediate and high iron overload. Nine patients with different levels of iron overload were studied in 4 multivendor devices and 8 of them were studied twice in the machine where the model was developed. The phantom was analysed in the same equipment and 14 times in the reference machine. Results . FeCl3 solutions containing 0.3, 0.5, 0.6, and 1.2 mg Fe/mL were chosen to generate the phantom. The average of the intramachine variability for patients was 10% and for the intermachines 8%. For the phantom the intramachine coefficient of variation was always below 0.1 and the average of intermachine variability was 10% for moderate and 5% for high iron overload. Conclusion . The phantom reproduces the behavior of patients with moderate or high iron overload. The proposed method of calculating liver iron concentration is reproducible in several different 1.5 T systems.