Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection. (25th February 2021)

• Record Type: Journal Article
• Authors: Sherman, Amy C; Lu, Xiaoyan; Schneider, Eileen; Langston, Amelia; Ellis, Carla L; Pastan, Stephen; Bhatnagar, Julu; Reagan-Steiner, Sarah; Annambhotla, Pallavi; Lindstrom, Stephen; Mehta, Aneesh; Pouch, Stephanie M; Sexton, Marybeth E
• Is Part Of: Open forum infectious diseases. Volume 8:Number 3(2021)
• Publication Date: 2021-02-25
• Subjects: adenovirus -- renal transplantation -- brincidofovir; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab092
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.