Feminizing adrenal tumor identified by plasma steroid profiling. (30th November 2021)

• Record Type: Journal Article
• Authors: Vogt, Elinor Chelsom; Hammerling, Kathrin; Sorbye, Halfdan; Heie, Anette; Sulen, Andre; Ueland, Grethe; Husebye, Eystein; Methlie, Paal
• Is Part Of: Endocrinology, diabetes & metabolism case reports. (2021)
• Publication Date: 2021-11-30
• Subjects: Adult -- Male -- White -- Norway; Adrenal -- Adrenal; Surgery; Novel diagnostic procedure -- November -- 2021; Endocrinology -- Periodicals; Diabetes -- Periodicals; Diabetes Mellitus; Endocrinology; Diabetes; Endocrinology; Case Reports; Periodicals; Periodicals; 616.4
• DOI: 10.1530/EDM-21-0104
• Languages: English
• ISSNs: 2052-0573

Abstract

Abstract : Summary: Feminizing estrogen-secreting adrenocortical carcinomas (ACCs) are exceedingly rare and carry a poor prognosis. The most common presenting trait is gynecomastia, but enlarged breasts are also a frequent clinical finding in healthy men. Biochemical evaluation may be challenging. As such, there is a high risk of delayed diagnosis and treatment opportunity. Here, we present a case with an estrogen-producing ACC where the abnormal steroid profile obtained at the time of initial workup was essential for the prompt diagnosis. Wider adoption of liquid chromatography mass spectrometry-based steroid assays has potential to improve early diagnosis of feminizing estrogen-secreting ACC. Learning points: Feminizing estrogen-secreting adrenocortical carcinomas (ACCs) are a rare, but an important differential diagnosis in men with rapidly developing gynecomastia. Biochemical evaluation is essential for a prompt diagnosis. Steroid hormone profiling using liquid chromatography mass spectrometry technology has the potential to improve early diagnosis of feminizing estrogen-secreting ACC.