Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions. (22nd February 2015)

• Record Type: Journal Article
• Authors: Pokrywczynska, Marta; Gubanska, Iga; Drewa, Gerard; Drewa, Tomasz
• Other Names: Kneser Ulrich Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-02-22
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/613439
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Construction of the urinary bladder de novo using tissue engineering technologies is the "holy grail" of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM.