Antifungal Compounds against Candida Infections from Traditional Chinese Medicine. (28th December 2017)

• Record Type: Journal Article
• Authors: Liu, Xin; Ma, Zhiming; Zhang, Jingxiao; Yang, Longfei
• Other Names: Chorianopoulos Nikos Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-12-28
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/4614183
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Infections caused by Candida albicans, often refractory and with high morbidity and mortality, cause a heavy burden on the public health while the current antifungal drugs are limited and are associated with toxicity and resistance. Many plant-derived molecules including compounds isolated from traditional Chinese medicine (TCM) are reported to have antifungal activity through different targets such as cell membrane, cell wall, mitochondria, and virulence factors. Here, we review the recent progress in the anti- Candida compounds from TCM, as well as their antifungal mechanisms. Considering the diverse targets and structures, compounds from TCM might be a potential library for antifungal drug development.