Advancements in Developing Strategies for Sterilizing and Functional HIV Cures. (26th April 2017)

• Record Type: Journal Article
• Authors: Xu, Wei; Li, Haoyang; Wang, Qian; Hua, Chen; Zhang, Hanzhen; Li, Weihua; Jiang, Shibo; Lu, Lu
• Other Names: Garg Himanshu Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-04-26
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/6096134
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and reducing mortality of patients infected with human immunodeficiency virus (HIV). However, the eradication of latent HIV reservoirs remains a challenge for curing HIV infection (HIV cure) because of HIV latency in primary memory CD4 + T cells. Currently, two types of HIV cures are in development: a "sterilizing cure" and a "functional cure." A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without treatment. Based on these concepts, significant progress has been made in different areas. This review focuses on recent advancements and future prospects for HIV cures.