Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB. (6th January 2016)

• Record Type: Journal Article
• Authors: Engelmann, Christian; Haenold, Ronny
• Other Names: Moya Pablo R. Academic Editor.
• Is Part Of: Neural plasticity. Volume 2016(2016)
• Publication Date: 2016-01-06
• Subjects: Neuroplasticity -- Periodicals; 612.82
• DOI: 10.1155/2016/7027949
• Languages: English
• ISSNs: 2090-5904

Abstract

Abstract : Activation of nuclear factor kappa B (NF- κ B) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF- κ B dimers move to the nucleus to translate synaptic signals into altered gene expression. Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits. Recent research on transgenic mice with impaired or hyperactivated NF- κ B gave important insights into plasticity-related target gene expression that is regulated by NF- κ B. In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF- κ B in the aged and diseased brain that may directly or indirectly affect κ B-dependent transcription of synaptic genes.