Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling. (4th May 2021)

• Record Type: Journal Article
• Authors: Gergs, André; Hager, Jutta; Bruns, Eric; Preuss, Thomas G.
• Is Part Of: Environmental toxicology and chemistry. Volume 40:Number 6(2021)
• Page Start: 1706
• Page End: 1712
• Publication Date: 2021-05-04
• Subjects: General unified threshold model of survival -- Dynamic energy budget -- Insecticides -- Invertebrates -- Chironomus riparius -- Feeding inhibition; Pollution -- Environmental aspects -- Periodicals; Environmental chemistry -- Periodicals; 615.902
• DOI: 10.1002/etc.5027
• Languages: English
• ISSNs: 0730-7268

Abstract

Abstract: Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius . Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706–1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.