Transcriptomic analysis and ednrb expression in cochlear intermediate cells reveal developmental differences between inner ear and skin melanocytes. (2nd February 2021)

• Record Type: Journal Article
• Authors: Renauld, Justine M.; Davis, William; Cai, Tiantian; Cabrera, Claudia; Basch, Martin L.
• Is Part Of: Pigment cell & melanoma research. Volume 34:Number 3(2021)
• Page Start: 585
• Page End: 597
• Publication Date: 2021-02-02
• Subjects: cochlea -- development -- EdnrB -- intermediate cells -- melanocytes -- stria vascularis; Melanoma -- Periodicals; Chromatophores -- Periodicals; Animal pigments -- Periodicals; 616.99477
• DOI: 10.1111/pcmr.12961
• Languages: English
• ISSNs: 1755-1471

Abstract

Abstract: In the inner ear, the neural crest gives rise to the glia of the VIII ganglion and two types of melanocytic cells: The pigmented cells of the vestibular system and intermediate cells of the stria vascularis. We analyzed the transcriptome of neonatal intermediate cells in an effort to better understand the development of the stria vascularis. We found that the expression of endothelin receptor B, which is essential for melanocyte development, persists in intermediate cells long after birth. In contrast, skin melanocytes rapidly downregulate the expression of EdnrB . Our findings suggest that endothelins might have co‐opted new functions in the inner ear during evolution of the auditory organ.