Prognosis and risk factors associated with asymptomatic intracranial hemorrhage after endovascular treatment of large vessel occlusion stroke: a prospective multicenter cohort study. (27th October 2020)

• Record Type: Journal Article
• Authors: Constant Dit Beaufils, P.; Preterre, C.; De Gaalon, S.; Labreuche, J.; Mazighi, M.; Di Maria, F.; Sibon, I.; Marnat, G.; Gariel, F.; Blanc, R.; Gory, B.; Consoli, A.; Zhu, F.; Richard, S.; Fahed, R.; Desal, H.; Lapergue, B.; Guillon, B.; Bourcier, R.
• Other Names: Piotin Michel investigator.; Blanc Raphael investigator.; Redjem Hocine investigator.; Escalard Simon investigator.; Desilles Jean‐Philippe investigator.; Ciccio Gabriele investigator.; Smajda Stanislas investigator.; Maier Benjamin investigator.; Mazighi Mikael investigator.; Obadia Mikael investigator.; Sabben Candice investigator.; Peres Roxanne investigator.; Corabianu Ovide investigator.; de Broucker Thomas investigator.; Smadja Didier investigator.; Alamowitch Sonia investigator.; Ille Olivier investigator.; Manchon Eric investigator.; Garcia Pierre‐Yves investigator.; Taylor Guillaume investigator.; Ben Maacha Malek investigator.; Wang Adrien investigator.; Evrard Serge investigator.; Tchikviladze Maya investigator.; Ajili Nadia investigator.; Lapergue Bertrand investigator.; Weisenburger David investigator.; Gorza Lucas investigator.; Buard Géraldine investigator.; Coskun Oguzhan investigator.; Consoli Arturo investigator.; Di Maria Federico investigator.; Rodesh Georges investigator.; Zimatore Sergio investigator.; Leguen Morgan investigator.; Gratieux Julie investigator.; Pico Fernando investigator.; Rakotoharinandrasana Haja investigator.; Tassan Philippe investigator.; Poll Roxanna investigator.; Marinier Sylvie investigator.; Nighoghossian Norbert investigator.; Riva Roberto investigator.; Eker Omer investigator.; Turjman Francis investigator.; Derex Laurent investigator.; Cho Tae‐Hee investigator.; Mechtouff Laura investigator.; Lukaszewicz Anne‐Claire investigator.; Philippeau Frédéric investigator.; Cakmak Serkan investigator.; Blanc‐Lasserre Karine investigator.; Vallet Anne‐Evelyne investigator.; Marnat Gaultier investigator.; Gariel Florent investigator.; Barreau Xavier investigator.; Berge Jérôme investigator.; Veunac Louis investigator.; Menegon Patrice investigator.; Sibon Igor investigator.; Lucas Ludovic investigator.; Olindo Stéphane investigator.; Renou Pauline investigator.; Sagnier Sharmila investigator.; Poli Mathilde investigator.; Debruxelles Sabrina investigator.; Tourdias Thomas investigator.; Liegey Jean‐Sebastien investigator.; Bourcier Romain investigator.; Detraz Lili investigator.; Daumas‐Duport Benjamin investigator.; Alexandre Pierre‐Louis investigator.; Roy Monica investigator.; Lenoble Cédric investigator.; L'allinec Vincent investigator.; Girot Jean‐Baptiste investigator.; Desal Hubert investigator.; Guillon Benoît investigator.; de Gaalon Solène investigator.; Preterre Cécile investigator.; Gory Benjamin investigator.; Bracard Serge investigator.; Anxionnat René investigator.; Braun Marc investigator.; Derelle Anne‐Laure investigator.; Tonnelet Romain investigator.; Liao Liang investigator.; Zhu François investigator.; Schmitt Emmanuelle investigator.; Planel Sophie investigator.; Richard Sébastien investigator.; Humbertjean Lisa investigator.; Mione Gioia investigator.; Lacour Jean‐Christophe investigator.; Bonnerot Mathieu investigator.; Riou‐Comte Nolwenn investigator.; Macian‐Montoro Francisco investigator.; Saleme Suzanna investigator.; Mounayer Charbel investigator.; Rouchaud Aymeric investigator.; Costalat Vincent investigator.; Arquizan Caroline investigator.; Dargazanli Cyril investigator.; Gascou Grégory investigator.; Lefèvre Pierre‐Henri investigator.; Derraz Imad investigator.; Riquelme Carlos investigator.; Gaillard Nicolas investigator.; Mourand Isabelle investigator.; Corti Lucas investigator.; Francois Eugene investigator.; Vannier Stéphane investigator.; Ferre Jean‐Christophe investigator.; Raoult Helene investigator.; Ronziere Thomas investigator.; Lassale Maria investigator.; Paya Christophe investigator.; Gauvrit Jean‐Yves investigator.; Tracol Clément investigator.; Langnier‐Lemercier Sophie investigator.; Samson Yves investigator.; Rosso Charlotte investigator.; Leger Anne investigator.; Deltour Sandrine investigator.; Clarencon Frederic investigator.; Shotar Eimad investigator.; Spelle Laurent investigator.; Denier Christian investigator.; Chassin Olivier investigator.; Chalumeau Vanessa investigator.; Caroff Jildaz investigator.; Chassin Olivier investigator.; Venditti Laura investigator.; Turc Guillaume investigator.; Naggara Olivier investigator.; Boulouis Gregoire investigator.; Ben Hassen Waghih investigator.; Seners Pierre investigator.; Viguier Alain investigator.; Cognard Christophe investigator.; Januel Anne Christine investigator.; Olivot Jean‐Marc investigator.; Raposo Nicolas investigator.; Bonneville Fabrice investigator.; Touze Emmanuel investigator.; Barbier Charlotte investigator.; Schneckenburger Romain investigator.; Boulanger Marion investigator.; Cogez Julien investigator.; Guettier Sophie investigator.;
• Is Part Of: European journal of neurology. Volume 28:Number 1(2021)
• Page Start: 229
• Page End: 237
• Publication Date: 2020-10-27
• Subjects: asymptomatic -- endovascular treatment -- intracerebral hemorrhage -- prognosis -- stroke; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14539
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome and to identify risk factors for aICH after EVT. Methods: Patients with AIS attributable to anterior circulation large vessel occlusion who underwent EVT were enrolled in a multicenter prospective registry. Based on imaging performed 22–36 h post‐EVT, we included patients with no intracranial hemorrhage (ICH) or aICH. Poor outcome defined as a 3‐month modified Rankin Scale (mRS) score 4–6 and overall 3‐month mRS score distribution were compared according to presence/absence of aICH, and aICH subtype using logistic regression. We assessed the risk factors of aICH using a multivariate logistic regression model. Results: Of the 1526 patients included in the study, 653 (42.7%) had aICH. Patients with aICH had a higher rate of poor outcome: odds ratio (OR) 1.88 (95% confidence interval [CI] 1.44–2.44). Shift analysis of mRS score found a fully adjusted OR of 1.79 (95% CI 1.47–2.18). Hemorrhagic infarction (OR 1.63 [95% CI 1.22–2.18]) and parenchymal hematoma (OR 2.99 [95% CI 1.77–5.02]) were associated with higher risk of poor outcome. Male sex, diabetes, coronary artery disease, baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early Computed Tomography Score, number of passes and onset to groin puncture time were independently associated with aICH. Conclusions: Patients with aICH, irrespective of the radiological pattern, have a worse functional outcome at 3 months compared with those without ICH after EVT for AIS. The number of EVT passes and the time from onset to groin puncture are factors that could be modified to reduce deleterious ICH. Abstract : In a prospective multicenter cohort study, asymptomatic intracranial hemorrhages do not seem to be so well named. Patients who suffer asymptomatic intracranial hemorrhages, irrespectively of the radiological pattern, have a worse functional outcome at 3‐months compared with those without intracranial hemorrhage after endovascular treatment for acute ischemic stroke. The number of endovascular treatment passes and the time from onset to groin puncture are factors that could be modified to reduce these deleterious ICH.