Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials. (24th January 2012)

• Record Type: Journal Article
• Authors: Amos, Keith D.; Adamo, Barbara; Anders, Carey K.
• Other Names: Chu Quyen D. Academic Editor.
• Is Part Of: International journal of breast cancer. Volume 2012(2012)
• Publication Date: 2012-01-24
• Subjects: Breast -- Cancer -- Periodicals; Periodicals; Breast Neoplasms; Breast -- Cancer; Periodicals; Periodicals; 616.99449
• DOI: 10.1155/2012/385978
• Languages: English
• ISSNs: 2090-3170

Abstract

Abstract : Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis despite the high rates of response to chemotherapy. This scenario highlights the need to develop novel therapies and/or treatment strategies to reduce the mortality associated with TNBC. The neoadjuvant setting provides a model for rapid assessment of treatment efficacy with smaller patient accruals and over shorter periods of time compared to the traditional adjuvant setting. In addition, a clear surrogate endpoint of improved survival, known as pathologic complete response, already exists in this setting. Here, we review current data from completed and ongoing neoadjuvant clinical trials for TNBC.