Diabetes mellitus as a vaccine-effect modifier: a review. (3rd May 2020)

• Record Type: Journal Article
• Authors: Verstraeten, Thomas; Fletcher, Mark A.; Suaya, Jose A.; Jackson, Sally; Hall-Murray, Cassandra K.; Scott, Daniel A.; Schmöle-Thoma, Beate; Isturiz, Raul E.; Gessner, Bradford D.
• Is Part Of: Expert review of vaccines. Volume 19:Number 5(2020)
• Page Start: 445
• Page End: 453
• Publication Date: 2020-05-03
• Subjects: Diabetes mellitus -- effect modifier -- efficacy -- effectiveness -- immunogenicity; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1080/14760584.2020.1760098
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: Introduction: Diabetes mellitus (DM) is a highly prevalent, chronic condition in adults worldwide. Little is known about the potential role of diabetes as an effect modifier of vaccine protective responses. Areas covered: We conducted a literature review of the immunogenicity, efficacy and effectiveness of immunization in individuals, in studies that compared subjects with DM (DM+) and without DM (DM-). We found few published studies, which were only for vaccines against hepatitis B, influenza, pneumococcal disease, or varicela zoster. Except for a consistent attenuation of the immune response to hepatitis B vaccine among DM+ individuals, we found little other consistent evidence for DM as an effect modifier of vaccine responses. Expert opinion: There are substantial gaps in our knowledge of the impact of DM on the immune response to immunization or effect of vaccination.