Antibody Testing in Atypical Optic Neuritis. (17th August 2020)

• Record Type: Journal Article
• Authors: Truong-Le, Melanie; Chwalisz, Bart
• Is Part Of: Seminars in ophthalmology. Volume 35:Number 5/6(2020)
• Page Start: 287
• Page End: 295
• Publication Date: 2020-08-17
• Subjects: Atypical optic neuritis -- neuromyelitis optica spectrum disorder -- CRMP-5 antibody -- aquaporin-4 antibody -- MOG antibody; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Surgery -- Periodicals; 617.7005
• DOI: 10.1080/08820538.2020.1820047
• Languages: English
• ISSNs: 0882-0538

Abstract

ABSTRACT: Optic neuritis (ON) is a common manifestation of central nervous system demyelinating disorders such as multiple sclerosis (MS). The last two decades have seen increasing recognition of atypical optic neuritis syndromes, driven in large part by characterization of demyelinating diseases associated with antibodies to aquaporin 4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG). Given their increased importance in the workup of ON, familiarity with serological tests for ON has become essential for ophthalmologists. This review will discuss technological aspects, performance, and clinical implications of serological tests for atypical ON.