Docking Applied to the Study of Inhibitors of c-Met Kinase. (13th December 2011)

• Record Type: Journal Article
• Authors: Gavernet, Luciana; Palestro, Pablo Hernan; Bruno-Blanch, Luis
• Other Names: Liu B.-T. Academic Editor.; Liwo A. Academic Editor.
• Is Part Of: ISRN physical chemistry. Volume 2012(2012)
• Publication Date: 2011-12-13
• Subjects: Chemistry, Physical and theoretical -- Periodicals; Chemistry, Physical and theoretical; 35.10 physical chemistry: general; Periodicals; Electronic journals; 541
• DOI: 10.5402/2012/391897
• Languages: English
• ISSNs: 2090-7761

Abstract

Abstract : Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.