Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis. (16th July 2017)

• Record Type: Journal Article
• Authors: Cantatore, Francesco Paolo; Maruotti, Nicola; Corrado, Addolorata; Ribatti, Domenico
• Other Names: Nanki Toshihiro Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-07-16
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/5345673
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.