ALSUntangled #62: vitamin C. Issue 5 (3rd July 2022)

• Record Type: Journal Article
• Authors: Bedlack, Richard; Barkhaus, Paul; Carter, Greg; Crayle, Jesse; Mcdermott, Christopher; Pattee, Gary; Polak, Meraida; Salmon, Kristiana; Wicks, Paul
• Is Part Of: Amyotrophic lateral sclerosis and frontotemporal degeneration. Volume 23:Issue 5/6(2022)
• Page Start: 476
• Page End: 479
• Publication Date: 2022-07-03
• Subjects: Vitamin C -- acorbic acid -- ascorbate -- clinical trials -- therapy -- models; 616.839
• DOI: 10.1080/21678421.2021.1946088
• Languages: English
• ISSNs: 2167-8421

Abstract

Abstract: Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. However, a small human trial showed no benefit. Given this negative trial, we do not currently advise vitamin C as an ALS treatment.