Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications. (12th November 2017)

• Record Type: Journal Article
• Authors: Valdés-Rives, Silvia Anahi; Casique-Aguirre, Diana; Germán-Castelán, Liliana; Velasco-Velázquez, Marco A.; González-Arenas, Aliesha
• Other Names: Pasqualetti Francesco Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-11-12
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/7403747
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.