Labor Induction with Orally Administrated Misoprostol: A Retrospective Cohort Study. (18th September 2017)

• Record Type: Journal Article
• Authors: Wallstrom, Tove; Jarnbert-Pettersson, Hans; Stenson, David; Akerud, Helena; Darj, Elisabeth; Gemzell-Danielsson, Kristina; Wiberg-Itzel, Eva
• Other Names: Tinelli Andrea Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-09-18
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/6840592
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Introduction. One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings. Material and Methods. Retrospective cohort study of 4002 singleton pregnancies with a gestational age ≥34 w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously used methods of labor induction were compared with misoprostol given as a solution to drink, every second hour. Main outcome is as follows: Cesarean Section (CS) rate, acid-base status in cord blood, Apgar score < 7, 5′, active time of labor, and blood loss > 1500 ml (PPH). Results. The proportion of CS decreased from 26% to 17% when orally given solution of misoprostol was introduced at the clinic (p < 0.001 ). No significant difference in the frequency of low Apgar score (p = 0.3 ), low aPh in cord blood (p = 0.1 ), or PPH (p = 0.4 ) between the different methods of induction was studied. After adjustment for different risk factor for CS the only method of induction which was associated with CS was d i n o p r o s t o n ⁎ ⁎ (Propess®) (aor = 2.9 (1.6–5.2)). Conclusion. Induction of labor with misoprostol, given as an oral solution to drink every second hour, gives a low rate of CS, without affecting maternal or fetal outcome.