Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment. (5th February 2017)

• Record Type: Journal Article
• Authors: Tsunekawa, Taichi; Kaneko, Hiroki; Takayama, Kei; Hwang, Shiang-Jyi; Oishi, Akio; Nagasaka, Yosuke; Ye, Fuxiang; Iwase, Takeshi; Nonobe, Norie; Ueno, Shinji; Ito, Yasuki; Yasuda, Shunsuke; Matsuura, Toshiyuki; Shimizu, Hideyuki; Suzumura, Ayana; Kataoka, Keiko; Terasaki, Hiroko
• Other Names: Georgalas Ilias Academic Editor.
• Is Part Of: BioMed research international. Volume 2017(2017)
• Publication Date: 2017-02-05
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2017/3427319
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Purpose. We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD. Methods. The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD. The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis. Results. The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were 23.68 ± 43.00, 12.07 ± 15.36 days, 155.85 ± 86.67 degrees, and 37000 ± 67100 pixels, respectively. Five eyes with RRD had vitreous hemorrhage preoperatively. The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β = 0.699 ) and the time from onset of RRD to vitrectomy (β = 0.358 ) but not with the range of RD or presence of vitreous hemorrhage. Conclusion. The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration.