Inside Cover: Selenylation Chemistry Suitable for On‐Plate Parallel and On‐DNA Library Synthesis Enabling High‐Throughput Medicinal Chemistry (Angew. Chem. Int. Ed. 35/2022). Issue 35 (4th July 2022)

• Record Type: Journal Article
• Authors: Xu, Hongtao; Wang, Yan; Dong, Hewei; Zhang, Yiyuan; Gu, Yuang; Zhang, Shuning; Meng, Yu; Li, Jie; Shi, Xiao Jie; Ji, Qun; Liu, Lili; Ma, Peixiang; Ma, Fei; Yang, Guang; Hou, Wei
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 35(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-04
• Subjects: Click Chemistry -- DNA-Encoded Library -- Modular Synthesis -- Selenium -- Selenylation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202209209
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Selenium is an emerging versatile player in medicinal chemistry. In their Research Article (e202206516 ), Hongtao Xu, Fei Ma, Guang Yang, Wei Hou et al. introduce a bioinspired SeClick chemistry between indole and benzoselenazole, which can be used in on‐plate parallel synthesis of indole‐selenide libraries and selenium containing DNA‐encoded libraries ( Se DELs) in a modular and predictable way, thereby boosting the development of seleno‐medicinal chemistry in the near future.