Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility. Issue 2 (25th July 2022)

• Record Type: Journal Article
• Authors: Jia, Xingyu; Chen, Wenchao; Chen, Wei; Liao, Yuxiang; Zhou, Jingying; Yuan, Li; Lin, Huiran; Bian, Jun
• Is Part Of: Precision medical sciences. Volume 11:Issue 2(2022)
• Page Start: 82
• Page End: 86
• Publication Date: 2022-07-25
• Subjects: glioma -- miR‐34b/c -- polymorphism -- rs4938723 -- susceptibility; Personalized medicine -- Periodicals; Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; 616.994
• DOI: 10.1002/prm2.12067
• Languages: English
• ISSNs: 2642-2514

Abstract

Abstract: Gliomas, the most common type of primary intracranial tumor, arise from the brain's glial cells and constitute 30% of all brain and central nervous system tumors. MiR‐34b/c plays an important role in colorectal cancer and other cancers, but its role in glioma is unknown. In this study, we attempted to assess the effect of rs4938723 T > C in miR‐34b/c on the susceptibility of glioma Chinese children. Odds ratios and 95% confidence intervals (CIs) were calculated to evaluate the association between the selected polymorphism and glioma susceptibility. Our results showed that there is no significant association between this polymorphism and the risk of glioma in Chinese children. However, stratified analysis showed that the rs4938723 TC/CC genotype significantly reduced the risk of glioma in participants under 60 months of age (adjusted OR = 0.56, 95% CI = 0.35–0.88, p = .013). Overall, our study indicates that miR‐34b/c rs4938723 T > C polymorphism may have a weak influence on glioma susceptibility. Nevertheless, these findings need to be validated in well‐designed studies with larger sample sizes and different populations. Abstract : We performed the first association study in a relatively large sample consisting of 314 patients with glioma and 380 cancer‐free controls recruited from China by genotyping the miR‐34b/c rs4938723 T > C. The genetic risk score showed non‐significant associations between miR‐34b/c rs4938723 T > C and glioma risk. A significantly decreased risk of glioma was observed in rs4938723 TC/CC genotype significantly reduced the risk of glioma in participants under 60 months of age (adjusted OR = 0.56, 95% CI = 0.35–0.88, p = .013).