Detecting lymph node metastasis of esophageal cancer on dual-energy computed tomography. (January 2022)

• Record Type: Journal Article
• Authors: Sun, Xuyang; Niwa, Tetsu; Ozawa, Soji; Endo, Jun; Hashimoto, Jun
• Is Part Of: Acta radiologica. Volume 63:Number 1(2022)
• Page Start: 3
• Page End: 10
• Publication Date: 2022-01
• Subjects: Esophageal cancer -- lymph node metastasis -- dual-energy computed tomography -- iodine concentration -- fat fraction; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185120980144
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Using conventional computed tomography (CT), the accurate diagnosis of lymph node (LN) metastasis of esophageal cancer is difficult. Purpose: To examine dual-energy CT parameters to predict LN metastasis preoperatively in patients with esophageal cancer. Material and Methods: Twenty-six consecutive patients who underwent dual-energy CT before an esophageal cancer surgery (19 patients with LN metastases) were analyzed. The included LNs had a short-axis diameter of ≥4 mm and were confirmed to be resected on postoperative CT. Their short-axis diameter, CT value, iodine concentration (IC), and fat fraction were measured on early- and late-phase contrast-enhanced dual-energy CT images and compared between pathologically confirmed metastatic and non-metastatic LNs. Results: In total, 51 LNs (34 metastatic and 17 non-metastatic) were included. In the early phase, IC and fat fraction were significantly lower in the metastatic than in the non-metastatic LNs (IC = 1.6 mg/mL vs. 2.2 mg/mL; fat fraction = 20.3% vs. 32.5%; both P < 0.05). Furthermore, in the late phase, IC and fat fraction were significantly lower in the metastatic than in the non-metastatic LNs (IC = 2.0 mg/mL vs. 3.0 mg/mL; fat fraction = 20.4% vs. 33.0%; both P < 0.05). Fat fraction exhibited accuracies of 82.4% and 78.4% on early- and late-phase images, respectively. Conversely, short-axis diameter and CT value on both early- and late-phase images were not significantly different between the metastatic and non-metastatic LNs ( P > 0.05). Conclusion: Using dual-energy CT images, IC and fat fraction are useful for diagnosing LN metastasis in patients with esophageal cancer.