Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non‐steroidal anti‐inflammatory drugs. Issue 4 (29th June 2022)

• Record Type: Journal Article
• Authors: Perić, Aleksandar; Matković, Svjetlana; Barać, Aleksandra; Vukadinović, Tijana; Čvorović, Ljiljana; Vojvodić, Danilo
• Is Part Of: Laryngoscope investigative otolaryngology. Volume 7:Issue 4(2022)
• Page Start: 928
• Page End: 934
• Publication Date: 2022-06-29
• Subjects: aspirin -- bradykinin -- hypersensitivity -- nasal polyps -- neurogenic inflammation -- sinusitis -- substance P; Otolaryngology -- Periodicals; Laryngoscopy -- Periodicals; Otolaryngology; Otolaryngology; Periodicals; Periodicals; 617.51
• DOI: 10.1002/lio2.851
• Languages: English
• ISSNs: 2378-8038

Abstract

Abstract: Objective: The role of neurogenic inflammation in pathogenesis of chronic rhinitis is well known. However, very little is known about its importance in pathogenesis of nasal polyposis (NP), especially in form of NP which appears as a part of aspirin‐exacerbated respiratory disease (AERD). The aim of this study was to examine the concentrations of neuropeptides substance P (SP) and bradykinin (BK) in nasal secretions of patients with NP. Methods: Fourteen patients with NP as a part of AERD with mild persistent asthma, 14 patients with NP without aspirin sensitivity, and 14 control subjects without nasal inflammation (C) entered this cross‐sectional study. Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed. The concentrations of SP and BK were measured in the nasal secretion samples using commercial human enzyme immunoassay kits. Results: The concentration of SP in nasal secretions was significantly higher in NP patients without aspirin sensitivity and AERD patients compared to controls ( p = .022; p < .0001, respectively), but higher in AERD than in non‐AERD patients ( p = .018). The level of BK in nasal fluid was higher in non‐AERD and AERD NP patients than in controls ( p < .0001; p < .0001, respectively), but also higher in AERD than in non‐AERD patients ( p < .0001). We found high positive correlations between BK in nasal fluid and Lund–Mackay computed tomography (CT) score in both non‐AERD and AERD groups of NP patients. Conclusion: Our results suggest more intense release of SP and BK from the nasal mucosa in patients with AERD than in patients with NP who do not have aspirin sensitivity. The strong correlation between concentration of BK in nasal secretions and CT score suggests that BK in nasal fluid could be used as a marker for disease severity as measured by the Lund–Mackay score. Abstract : The role of neurogenic inflammation in pathogenesis of chronic allergic and non‐allergic rhinitis is well known, but very little is known about its importance in pathogenesis of chronic rhinosinusitis with nasal polyposis (NP). Our study is the first to show that the level of substance P and bradykinin production in the mucosal layer of NP patients with aspirin‐exacerbated respiratory disease (AERD) is significantly higher compared to patients with NP who do not have sensitivity to non‐steroid anti‐inflammatory drugs (NSAIDs). The concentration of bradykinin in nasal secretions strongly correlates with the degree of NP extent, evaluated by the Lund–Mackay CT score.