Self‐reported executive function problems in adults born very low birthweight. Issue 5 (23rd May 2022)

• Record Type: Journal Article
• Authors: Kim, Hyun Min; Horwood, L. John; Harris, Sarah L.; Bora, Samudragupta; Darlow, Brian A.; Woodward, Lianne J.
• Other Names: Anderson Peter J. guestEditor.; Zeitlin Jennifer guestEditor.
• Is Part Of: Paediatric and perinatal epidemiology. Volume 36:Issue 5(2022)
• Page Start: 643
• Page End: 653
• Publication Date: 2022-05-23
• Subjects: adult -- BRIEF -- executive function -- outcome -- very low birthweight -- very preterm; Pediatrics -- Periodicals; Perinatology -- Periodicals; Pediatric epidemiology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; 618.92
• DOI: 10.1111/ppe.12891
• Languages: English
• ISSNs: 0269-5022

Abstract

Abstract: Background: Executive function difficulties are common among children born very preterm and/or very low birthweight (<1500 g; VLBW), but little is known about whether they persist into adulthood. Objectives: Examine the nature and pattern of self‐reported executive functioning at 23 and 28 years of age using data from a national cohort study of adults born VLBW and a comparison group of same‐age full‐term (FT) born adults. Also examined were associations between executive function difficulties and socio‐economic outcomes. Methods: All infants born VLBW in New Zealand during 1986 were prospectively included in an audit of retinopathy of prematurity ( n = 413), with 250 (77% of survivors) followed to median age 28 years. A comparison group of FT adults was also recruited at age 23 and followed to 28 years ( n = 100). Across both adult assessments, executive functioning was assessed using the Behaviour Rating Inventory of Executive Function—Adult Version (BRIEF‐A) and analysed with semi‐parametric models to examine the effects of age and group on executive function. Results: At 23 and 28 years, VLBW adults had increased risk of executive function impairment compared with FT adults in behaviour regulation (relative risk [CI] 2.37, 95% confidence interval (CI)1.27, 4.45), meta‐cognition (RR 6.03, 95% CI 2.18, 16.78) and global functioning (RR 3.20, 95% CI 1.40, 7.28). Impaired global executive functioning was associated with lower socio‐economic status (regression estimate [ b ] = −0.43, 95% CI −0.59, −0.27) and a reduced likelihood of home ownership by age 28 years (RR 0.98, 95% CI 0.96, 1.00), even after controlling for sex, ethnicity and parental socio‐economic backgrounds for both groups. Conclusion(s): VLBW‐born adults continue to experience more executive function difficulties in their everyday life relative to term controls at age 28 years. These difficulties were negatively associated with their socio‐economic opportunities as young adults.