Clinical significance of serum ferritin in patients with systemic sclerosis. Issue 8 (9th July 2022)

• Record Type: Journal Article
• Authors: Jiang, Yanting; Li, Xi; Zhou, Wei; Jin, Min; Li, Sihui; Lao, Yuehong; Zhu, Haiqing; Wang, Jian
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 8(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-09
• Subjects: autoantibody -- autoimmune diseases -- inflammation -- serum ferritin -- systemic sclerosis; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24597
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Objective: The purpose of this study was to explore the clinical significance of serum ferritin (SF) in patients with systemic sclerosis (SSc). Methods: The levels of SF were measured in 115 patients with SSc and 117 healthy controls (HCs). Clinical characteristics and laboratory indexes between the high ferritin SSc group and the normal ferritin SSc group were analyzed. Results: The level of SF in SSc patients was significantly higher than that in HCs (319.78 [179, 554.33] ng/ml vs. 99 [49.03, 164.29] ng/ml, p < 0.01). Compared with the normal ferritin SSc group, the high ferritin SSc group was more likely to develop skin diffuse cutaneous SSc, fingertip arthralgia, and cardiac involvement. In addition, the levels of glutamine transaminase (GGT), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase isoenzyme‐MB (CK‐MB), lactate dehydrogenase (LD), immunoglobulin G (IgG), immunoglobulin A (IgA), C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), and the positive rate of anti‐Scl70 antibody in the high ferritin SSc group were significantly higher (each p < 0.05). SF was positively correlated with GGT, ALT, CK, CK‐MB, LD, IgA, CRP, and ESR (each p < 0.05). Multiple linear regression analysis showed that cardiac involvement, ALT, and ESR were independent influencing factors of SF in SSc. Conclusion: Our study shows that the level of SF in patients with SSc is increased, and the elevated SF is related to abnormal liver function, myocardial involvement, inflammatory status, and production of autoantibodies in SSc. Cardiac involvement, ALT, and ESR are independent factors affecting SF in SSc. Abstract : The level of SF in patients with SSc was significantly higher than that in HCs. The levels of GGT, ALT, CK, LD, IgG, IgA, CRP, ESR, and the positive rate of anti‐Scl70 antibody in the high ferritin SSc group were significantly higher than those in the normal ferritin SSc group (each p < 0.05). The results of Spearman correlation analysis showed that SF was positively correlated with GGT, AST, ALT, ALP, CK, LD, IgA, CRP, and ESR (each p < 0.05).