Abstract : Theranostics In article 2200517 by Heng Liu, Jingqin Fang, Xiao Chen, and co‐workers, intrinsically bioactive multifunctional nanocomposites (AMEC) which mediate antioxidation and anti‐neuroinflammation for targeted TBI theranostics are developed. AMECs effectively reduce lesion size and improve the cognition of TBI mice. More notably, T1‐T2 dual‐modal MRI and PAI of AMECs allow tracking of the drug delivery into the TBI lesion in vivo.