Frequency of TGF-β and IFN-γ Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients. (23rd July 2014)

• Record Type: Journal Article
• Authors: Grabulosa, Caren Cristina; Batista, Marcelo Costa; Cendoroglo, Miguel; Quinto, Beata Marie Redublo; Narciso, Roberto; Monte, Julio Cesar; Durão, Marcelino; Rizzo, Luiz Vicente; Santos, Oscar Fernando Pavão; Dalboni, Maria Aparecida
• Other Names: Lombardi Raul Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-07-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/904730
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Genetic variations in TGF- β and IFN- γ may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF- β, and rs2430561 (+874 T/A) from IFN- γ may be a risk factor for ICU patients to the development of AKI and/or death. In a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals. We observed a higher frequency to T/A genotype for IFN- γ (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF- β polymorphism in overall population. However, these polymorphisms have not been shown as a predictor of risk for AKI and death. We found an increased prevalence of high and intermediate producer phenotypes from TGF- β and IFN- γ, respectively, in patients in ICU setting. However, the studied genetic polymorphism of the TGF- β and IFN- γ was not associated as a risk factor for AKI or death in our population.