Challenges and Promise of Human Immunodeficiency Virus Remission. (15th February 2021)

• Record Type: Journal Article
• Authors: Li, Yijia; Mohammadi, Abbas; Li, Jonathan Z
• Is Part Of: Journal of infectious diseases. Volume 223:Number 1(2021)Supplement
• Page Start: S4
• Page End: S12
• Publication Date: 2021-02-15
• Subjects: HIV reservoir -- latency -- post-treatment controller -- provirus -- spontaneous controller; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa568
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication but it is unable to fully eradicate the HIV reservoir and treatment must be life-long. Progress toward a strategy for HIV remission will require overcoming key hurdles to fill gaps in our understanding of HIV persistence, but the identification of individuals who have attained sterilizing or functional HIV cure show that such a goal is achievable. In this review, we first outline challenges in targeting the HIV reservoir, including difficulties identifying HIV-infected cells, ongoing work elucidating the complex intracellular environment that contribute to HIV latency, and barriers to reactivating and clearing the HIV reservoir. We then review reported cases of HIV sterilizing cure and explore natural models of HIV remission and the promise that such HIV spontaneous and posttreatment controllers may hold in our search for a broadly-applicable strategy for the millions of patients living with HIV.