Association of HLA‐DRB1*09:01 with severe COVID‐19. (13th April 2021)
- Record Type:
- Journal Article
- Title:
- Association of HLA‐DRB1*09:01 with severe COVID‐19. (13th April 2021)
- Main Title:
- Association of HLA‐DRB1*09:01 with severe COVID‐19
- Authors:
- Anzurez, Alitzel
Naka, Izumi
Miki, Shoji
Nakayama‐Hosoya, Kaori
Isshiki, Mariko
Watanabe, Yusuke
Nakamura‐Hoshi, Midori
Seki, Sayuri
Matsumura, Takayuki
Takano, Tomohiro
Onodera, Taishi
Adachi, Yu
Moriyama, Saya
Terahara, Kazutaka
Tachikawa, Natsuo
Yoshimura, Yoshihiro
Sasaki, Hiroaki
Horiuchi, Hiroshi
Miyata, Nobuyuki
Miyazaki, Kazuhito
Koga, Michiko
Ikeuchi, Kazuhiko
Nagai, Hiroyuki
Saito, Makoto
Adachi, Eisuke
Yotsuyanagi, Hiroshi
Kutsuna, Satoshi
Kawashima, Akira
Miyazato, Yusuke
Kinoshita, Noriko
Kouno, Chiyoko
Tanaka, Kensuke
Takahashi, Yoshimasa
Suzuki, Tadaki
Matano, Tetsuro
Ohashi, Jun
Kawana‐Tachikawa, Ai
… (more) - Abstract:
- Abstract : HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA‐DRB1*09:01 and severe COVID‐19 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID‐19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID‐19.
- Is Part Of:
- HLA. Volume 98:Number 1(2021)
- Journal:
- HLA
- Issue:
- Volume 98:Number 1(2021)
- Issue Display:
- Volume 98, Issue 1 (2021)
- Year:
- 2021
- Volume:
- 98
- Issue:
- 1
- Issue Sort Value:
- 2021-0098-0001-0000
- Page Start:
- 37
- Page End:
- 42
- Publication Date:
- 2021-04-13
- Subjects:
- association -- coronavirus disease 2019 -- HLA -- Japan -- risk factor -- severe acute respiratory syndrome coronavirus 2
Immunogenetics -- Periodicals
Antigens -- Periodicals
HLA histocompatibility antigens -- Periodicals
571.9645 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2059-2310 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/tan.14256 ↗
- Languages:
- English
- ISSNs:
- 2059-2302
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 23404.xml