Association of HLA‐DRB1*09:01 with severe COVID‐19. (13th April 2021)

• Record Type: Journal Article
• Authors: Anzurez, Alitzel; Naka, Izumi; Miki, Shoji; Nakayama‐Hosoya, Kaori; Isshiki, Mariko; Watanabe, Yusuke; Nakamura‐Hoshi, Midori; Seki, Sayuri; Matsumura, Takayuki; Takano, Tomohiro; Onodera, Taishi; Adachi, Yu; Moriyama, Saya; Terahara, Kazutaka; Tachikawa, Natsuo; Yoshimura, Yoshihiro; Sasaki, Hiroaki; Horiuchi, Hiroshi; Miyata, Nobuyuki; Miyazaki, Kazuhito; Koga, Michiko; Ikeuchi, Kazuhiko; Nagai, Hiroyuki; Saito, Makoto; Adachi, Eisuke; Yotsuyanagi, Hiroshi; Kutsuna, Satoshi; Kawashima, Akira; Miyazato, Yusuke; Kinoshita, Noriko; Kouno, Chiyoko; Tanaka, Kensuke; Takahashi, Yoshimasa; Suzuki, Tadaki; Matano, Tetsuro; Ohashi, Jun; Kawana‐Tachikawa, Ai;
• Is Part Of: HLA. Volume 98:Number 1(2021)
• Page Start: 37
• Page End: 42
• Publication Date: 2021-04-13
• Subjects: association -- coronavirus disease 2019 -- HLA -- Japan -- risk factor -- severe acute respiratory syndrome coronavirus 2; Immunogenetics -- Periodicals; Antigens -- Periodicals; HLA histocompatibility antigens -- Periodicals; 571.9645
• DOI: 10.1111/tan.14256
• Languages: English
• ISSNs: 2059-2302

Abstract

Abstract : HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA‐DRB1*09:01 and severe COVID‐19 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID‐19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID‐19.