Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication. Issue 32 (1st August 2022)

• Record Type: Journal Article
• Authors: Sun, Hao; Dan, Jie; Liang, Yanmin; Li, Min; Zhuo, Junchen; Kang, Yi; Su, Zehui; Zhang, Qiuping; Wang, Jianlong; Zhang, Wentao
• Is Part Of: Nanoscale. Volume 14:Issue 32(2022)
• Page Start: 11693
• Page End: 11702
• Publication Date: 2022-08-01
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d2nr02828j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A zero-dimensional bimetallic MOF-based nanozyme Co–Fe NDs with good antibacterial activity and biocompatibility was prepared by reducing the dimensionality. Meanwhile, the K m of Co–Fe NDs was almost triple that of the precursor Co–Fe NSs. Abstract : The antibacterial strategy using cutting-edge metal–organic framework (MOF)-based nanozymes can effectively solve the problem caused by antibiotic resistance to protect human health and the environment; however it has been significantly limited by the complicated modification method and non-ideal catalytic activity. Herein, we report a facile dimensionality-reduction strategy to improve the catalytic activity of MOF-based nanozymes. By reducing the dimensionality of two-dimensional Co-TCPP(Fe) (Co–Fe NSs) to zero-dimensional Co-TCPP(Fe) (Co–Fe NDs), the peroxidase-like activity of the prepared bimetallic Co–Fe NDs was almost tripled. Consequently, the bimetallic Co–Fe NDs can highly efficiently catalyze the lower-concentration H2 O2 into reactive oxygen species (ROS), resulting in a favorable antibacterial effect against methicillin-resistant Staphylococcus aureus (MRSA). Meanwhile, Co–Fe NDs can effectively promote wound healing and water environment disinfection with good biocompatibility. This work reveals the potential of a zero-dimensional bimetallic MOF-based nanozyme in resisting drug-resistant bacteria and holds great promise for future clinical and environmental applications.