18F-Labelled Intermediates for Radiosynthesis by Modular Build-Up Reactions: Newer Developments. (23rd June 2014)

• Record Type: Journal Article
• Authors: Ermert, Johannes
• Other Names: Riss Patrick Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-06-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/812973
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : This brief review gives an overview of newer developments in 18 F-chemistry with the focus on small 18 F-labelled molecules as intermediates for modular build-up syntheses. The short half-life (<2 h) of the radionuclide requires efficient syntheses of these intermediates considering that multistep syntheses are often time consuming and characterized by a loss of yield in each reaction step. Recent examples of improved synthesis of 18 F-labelled intermediates show new possibilities for no-carrier-added ring-fluorinated arenes, novel intermediates for tri[ 18 F]fluoromethylation reactions, and 18 F-fluorovinylation methods.