Prognostic Histopathological and Molecular Markers on Prostate Cancer Needle-Biopsies: A Review. (27th August 2014)

• Record Type: Journal Article
• Authors: Hoogland, A. Marije; Kweldam, Charlotte F.; Leenders, Geert J. L. H. van
• Other Names: Doll Andreas Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-08-27
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/341324
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Prostate cancer is diverse in clinical presentation, histopathological tumor growth patterns, and survival. Therefore, individual assessment of a tumor's aggressive potential is crucial for clinical decision-making in men with prostate cancer. To date a large number of prognostic markers for prostate cancer have been described, most of them based on radical prostatectomy specimens. However, in order to affect clinical decision-making, validation of respective markers in pretreatment diagnostic needle-biopsies is essential. Here, we discuss established and promising histopathological and molecular parameters in diagnostic needle-biopsies.