Copper-catalyzed direct monofluoroalkenylation of C(sp3)–H bonds via decarboxylation of α-fluoroacrylic acids. Issue 17 (27th July 2022)

• Record Type: Journal Article
• Authors: Lu, Xiao-Yu; Chen, Xing-Ke; Gao, Meng-Ting; Sun, Xiao-Mei; Jiang, Run-Chuang; Wang, Jun-Chao; Yu, Li-Juan; Ge, Meng-Yuan; Wei, Zheng-Huan; Liu, Zi
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 17(2022)
• Page Start: 4712
• Page End: 4718
• Publication Date: 2022-07-27
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00977c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Herein, a protocol for the copper-catalyzed direct monofluoroalkenylation of C(sp 3 )–H bonds is reported. Abstract : Herein, a protocol for the copper-catalyzed direct monofluoroalkenylation of C(sp 3 )–H bonds is reported. A wide range of α-fluoroacrylic acids and C–H patterns were suitable reaction substrates, delivering the corresponding monofluoroalkenes with excellent Z -stereoselectivity. These are vital structural motifs in synthetic organic chemistry and pharmaceutical sciences. In addition to α-fluoroacrylic acids, β-fluoroacrylic acids were also compatible reaction substrates.