Broad application prospects of bone turnover markers in pediatrics. Issue 9 (10th August 2022)

• Record Type: Journal Article
• Authors: Zhang, Yiduo; Huang, Xiaocui; Li, Chao; Zhang, Jing; Yu, Xingnan; Li, Ye; Zhou, Wenjie; Yu, Fan
• Is Part Of: Journal of clinical laboratory analysis. Volume 36:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-10
• Subjects: ALP -- bone turnover markers -- clinical utility -- CTX -- metabolic disease -- osteocalcin -- pediatrics -- PINP; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.24656
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: Bone turnover markers (BTMs) have been studied for application in clinical medicine. However, BTMs in children are challenging, and few studies explore these BTMs in children. The application of BTMs is complicated mainly due to pre‐analytical factors, variable reference intervals of age‐ and sex‐related BTMs for adolescents and children in different regions and laboratories. Therefore, laboratory testing of BTMs is critical for understanding pediatric bone development and metabolism, which provides additional information about bone development and diseases. Methods: Literature search was conducted using the MeSH term "child" combined with the terms that bone turnover markers such as "osteocalcin, " "Procollagen type I N‐terminal propeptide, " "procollagen type I C‐terminal propeptide, " "osteocalcin, " "N‐terminal cross‐linked telopeptide, " and "C‐terminal cross‐linked telopeptide, " Several databases including Web of Science, Google Scholar, and PubMed were searched to obtain the relevant studies. Results: BTMs represent the combined effects of skeletal development, growth, and remodeling in children, which can be used in clinical pediatrics to assist in the diagnosis and prognosis of bone metabolic disorders. Conclusion: BTMs are clearly helpful for diagnosis and monitoring of bone growth and development as well as bone metabolic disorders. Abstract : Bone turnover markers (BTMs) have been evaluated for use in medicine; however, there are challenges to the interpretation of BTMs in children, in part, because there have been too few studies in children. BTMs represent the combined effects of the formation, growth, and remodeling of bone metabolism in children. The use of BTMs is complicated primarily due to pre‐analytical factors and variable reference intervals of age‐ and sex‐related BTMs for adolescents and children in different regions and laboratories. BTMs may be used for diagnosis and prognostic prediction of bone metabolic disease to support clinical pediatrics. Laboratory testing of BTMs is important for understanding pediatric bone development and metabolism, which provides additional information about bone development and disease. BTMs are useful for the diagnosis and monitoring of bone growth and development and bone metabolic disorders.