Long‐term evolutionary adaptation of SIVcpz toward HIV‐1 using a humanized mouse model. Issue 5 (28th August 2022)

• Record Type: Journal Article
• Authors: Schmitt, Kimberly; Curlin, James; Remling‐Mulder, Leila; Morrison, Jared; Moriarty, Ryan; Goff, Kelly; Stenglein, Mark; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh
• Is Part Of: Journal of medical primatology. Volume 51:Issue 5(2022)
• Page Start: 288
• Page End: 291
• Publication Date: 2022-08-28
• Subjects: HIV‐1 viral evolution -- modeling SIV evolution using humanized mice -- SIV cross‐species transmission -- SIVcpz evolution into HIV‐1 -- viral evolution in humanized mice; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12616
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV‐1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV‐1 Group M over the course of four generations. Higher initial viral load, increased CD4 + T‐cell decline, and nonsynonymous substitutions arose suggesting viral evolution.